Rapamycin reduces splenomegaly and lymphadenopathy in Common Variable Immunodeficiency ( CVID ) : A

A 54 year old female was hospitalised with anti-microbial-sensitive H. influenza pneumonia, her first major infection. Past medical history included prior motor vehicle accident, 160 pack year history of smoking and a recent diagnosis of chronic obstructive pulmonary disease (COPD). Medications on admission were Budesonide-Efomoterol, terbinafine and bupropion. There was no history of allergy, recent travel, sick contacts, recreational drug use or pets in the home. The patient was treated with 1.2g of IV Benzylpenicillin QID and a weaning dose of oral prednisone beginning at 50mg PO OD. She failed to clinically improve by Day 10 prompting further investigations.